ISSN (Print): 2618-7019
ISSN (Online): 3034-3534

Проект рекомендаций по цитоморфологической диагностике патологии уринарного тракта

Авторы: Савостикова М.В., Кудайбергенова А.Г., Федосеева Е.С., Козорезова Е.С., Воробьев С.Л., Горбань Н.А.

DOI: 10.17650/2618-7019-2019-2-1-2-52-67

PDF: https://journal.oncopathology.ru/article/OP_1_2_19-54-69.pdf

Представлен проект рекомендаций по цитоморфологической диагностике патологии уринарного тракта. В работе освещены основные моменты преаналитического этапа: получение материала, его приготовление и окраска. Представлены категории Парижской классификации 2016 г., отмечены основные цитоморфологические критерии оценки уринарной патологии в цитопрепаратах.

Савостикова М. В.1, Кудайбергенова А. Г.2, Федосеева Е. С.1, Козорезова Е. С.3, Воробьев С. Л.3, Горбань Н. А.1

1ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами Президента Российской Федерации; Россия, 121359 Москва, ул. Маршала Тимошенко, 15;

2ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России; Россия, 197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68;

3ООО «Национальный центр клинической морфологической диагностики»; Россия, 192283 Санкт-Петербург, ул. Олеко Дундича, 8, корп. 2, лит. А

1. Haber M.H. Pisse prophecy: a brief history of urinalysis. Clin Lab Med 1988;8(3):415–30. PMID: 3048852.

2. Hughes J.H., Raab S.S., Cohen M.B. The cytologic diagnosis of low-grade transitional cell carcinoma. Am J Clin Pathol (Pathology Patterns Reviews) 2000;114(suppl 1):S59–67. PMID: 11996171.

3. Long S.R., Cohen M.B. Classics in cytology: V. William Sanders and early urinary tract cytology. Diagn Cytopathol 1992;8:135–6. PMID: 1568411.

4. Fogazzi G.B., Garigali G. The clinical art and science of urine microscopy. Curr Opin Nephrol Hypertens 2003;12:625–32. PMID: 14564200. DOI: 10.1097/01. mnh.0000098769.18213.39.

5. Papanicolaou G.N., Marshall V.F. Urine sediment smears as a diagnostic procedure in cancers of the urinary tract. Science 1945;101:519–21. PMID: 17775845. DOI: 10.1126/science.101.2629.519.

6. Koss L.G., Melamed M.R., Kelly R.E. Further cytologic and histologic studies of bladder lesions in workers exposed to para-aminodiphenyl: progress report. J Natl Cancer Instit 1969;43:233–43. PMID: 5796385.

7. Murphy W.M., Sloway M.S., Jukkola A.F. et al. Urinary cytology and bladder cancer: the cellular features of transitional cell neoplasms. Cancer 1984;53:1555–65. PMID: 6697294.

8. Epstein J.I., Amin M.B., Reuter V.R. et al. The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. Am J Surg Pathol 1998;22:1435– 48. PMID: 9850170.

9. Ferlay J., Soerjomataram I., Dikshit R. et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136(5):E359–86. PMID: 25220842. DOI: 10.1002/ijc.29210.

10. DeMay R. The art & science of cytopathology. 2nd edn. Vol. 1. American Society for Clinical Pathology Press, 2012. P. 437.

11. Halling K.C., King W., Sokolova I.A. et al. A comparison of cytology and fluorescence in situ hybridization for the detection of urothelial carcinoma. J Urol 2000;164:1768–75. PMID: 11025767.

12. Roshdy M., Hammam O., Abdelsalam A. et al. The Utility of Fluorescence in situ Hybridization for Early Detection of Bladder Urothelial Carcinoma in Comparison with Urine Cytology. Life Sci 2014;11(11):806–11. PMID: 19949672. DOI: 10.3346/jkms.2009.24.6.1139.

13. Медицинские лабораторные технологии. Под ред. А.И. Карпищенко. T. 1. СПб.: Интермедика, 2002. 408 с. [Medical laboratory technologies. Ed. by A.I. Karpischenko. Vol. 1. Saint Petersbirg: Intermedika, 2002. 408 p. (In Russ.)].

14. Миронова И.И., Романова Л.А., Долгов В.В. Общеклинические исследования: моча, кал, ликвор, мокрота. М.: Триада, 2012. С. 5–103. [Mironova I.I., Romanova L.A., Dolgov V.V. Clinical laboratory investigations: urine, feces, cerebrospinal fluid, sputum. Moscow: Triada, 2012. Pp. 5–103. (In Russ.)].

15. Стандартизация аналитических технологий лабораторной медицины. Вып. 1. Под ред. В.В. Меньшикова. М.: Лабора, 2012. С. 109–129. [Standartization in laboratory medicine analytic technologies. Iss. 1. Ed. by V.V. Menshikov. M.: Labora, 2012. Pp. 109–129. (In Russ.)].

16. Rosenthal D.L., Wojcik E.M., Kurtycz D.F. The Paris System for Reporting Urinary Cytology. Nw York: Springer, 2016. Pp. 61–74.

17. Crabtree W.N., Murphy W.M. The value of ethanol as a fixative in urinary cytology. Acta Cytol 1980;24:452–5. PMID: 7001825.

18. Awad S., Allison S.P., Lobo D.N. The history of 0.9 % saline. Clin Nutr 2008;27:179–88. PMID: 18313809. DOI: 10.1016/j.clnu.2008.01.008.

19. Pomerat C.M., Overman R.R. Electrolytes and plasma expanders – I. Reaction of human cells in perfusion chambers with phase contrast, time-lapse cine records. Z Zellforsch Mikrosk Anat 1956;45:2–17. PMID: 13402069.

20. Руководство по цитологической диагностике опухолей человека. Под ред. А.С. Петровой, М.П. Птохова. М.: Медицина, 1976. С. 83. [Guidelines in cytological diagnostics of human tumors. Ed. by A.S. Petrova, M.P. Ptokhov. M.: Meditsina, 1976. P. 83. (In Russ.)].

21. Gill G.W. Cytopreparation: principles & practice. In: Essentials in cytopathology. Vol. 12. Ed. by D.L. Rosenthal. New York: Springer; 2013. Pp. 73–100.

22. Amin M.B., Smith S.C., Reuter V.E. et al. Update for the practicing pathologist: The International Consultation On Urologic Disease – European association of urology consultation on bladder cancer. Modern Pathology 2014;1:19. PMID: 25412849. DOI: 10.1038/modpathol. 2014.158.

23. Galed-Placed I., Valbuena-Ruvira L. Decoy cells and malignant cells coexisting in the urine from a transplant recipient with BK virus nephropathy and bladder adenocarcinoma. Diagn Cytopathol 2011;39:933–7. PMID: 22081531. DOI: 10.1002/dc.21579.

24. Geetha D., Tong B.C., Racusen L. et al. Bladder carcinoma in a transplant recipient: evidence to implicate the BK human polyomavirus as a causal transforming agent. Transplantation 2002;73:1933–6. PMID: 12131691.

25. Renshaw A.A. Subclassifying atypical urinary cytology specimens. Cancer 2000;90:222–9. DOI: 10.1002/1097-0142(20000825)90: 4%3C222::AID-CNCR4%3E3.0.CO;2-A.

26. Wojcik E.M. What should not be reported as atypia in urine cytology. J Am Soc Cytopathol 2015;4:30–6. DOI: 10.1016/j. jasc.2014.08.001.

27. Piaton E., Decaussin-Petrucci M., Mege- Lechevallier F. et al. Diagnostic terminology for urinary cytology reports including the new subcategories “atypical urothelial cells of undetermined significance” (AUC-US) and “cannot exclude high grade”(AUC-H). Cytopathology 2014;25:27–38. PMID: 23461719. DOI: 10.1111/cyt.12050.

28. Sternberg I., Rona R., Olsfanger S. et al. The clinical significance of class III (suspicious) urine cytology. Cytopathology 2011;22:329–33. PMID: 21114557. DOI: 10.1111/j.1365-2303.2010.00827.x.

29. VandenBussche C.J., Sathiyamoorthy S., Owens C.L. et al. The Johns Hopkins Hospital template for urologic cytology samples: parts II and III: improving the predictability of indeterminate results in urinary cytologic samples: an outcomes and cytomorphologic study. Cancer Cytopathol 2013;121:21–8. PMID: 23192913. DOI: 10.1002/cncy.21254.

30. Ton Nu T.N., Kassouf W., Ahmadi-Kaliji B. et al. The value of the “suspicious for urothelial carcinoma” cytology category: a correlative study of 4 years including 337 patients. Cancer Cytopathol 2014;122:796–803. PMID: 24909774. DOI: 10.1002/cncy.21449.

31. Renshaw A.A., Nappi D., Weinberg D.S. Cytology of grade 1 papillary transitional cell carcinoma. A comparison of cytologic, architectural and morphometric criteria in cytoscopically obtained urine. Acta Cytol 1996;40:676–82. PMID: 8693885. DOI: 10.1159/000333938.

32. Barkan G.A., Wojcik E.M., Nayar R. et al. The Paris System for Reporting Urinary Cytology: The Quest to Develop a Standardized Terminology. Acta Cytol 2016;60:185–97. DOI: 10.1159/000446270.

33. Raab S.S., Slagel D.D., Jensen C.S. et al. Low-grade transitional cell carcinoma of the urinary bladder: application of select cytologic criteria to improve diagnostic accuracy. Mod Pathol 1996;9:225–32. PMID: 8685219.

34. Raab S.S., Lenel J.C., Cohen M.B. Low grade transitional cell carcinoma of the bladder. Cytologic diagnosis by key features as identified by logistic regression analysis. Cancer 1994;74:1621–6. PMID: 8062194.

35. Xin W., Raab S.S., Michael C.W. Lowgrade urothelial carcinoma: reappraisal of the cytologic criteria on ThinPrep. Diagn Cytopathol 2003;29:125–9. PMID: 12951678. DOI: 10.1002/dc.10311.

36. Murphy W.M., Soloway M.S., Jukkola A.F. et al. Urinary cytology and bladder cancer. The cellular features of transitional cell neoplasms. Cancer 1984;53:1555–65. PMID: 6697294.

37. McCroskey Z., Pambuccian S.E., Kleitherms S. et al. Accuracy and interobserver variability of the cytologic diagnosis of low-grade urothelial carcinoma in instrumented urinary tract cytology specimens. Am J Clin Pathol 2015;144:902–8. PMID: 26572997. DOI: 10.1309/ AJCPE1O9YKMRSQKG.

38. Nathan N.A., Narayan E., Smith M.M., Horn M.J. Cell block cytology. Improved preparation and its efficacy in diagnostic cytology. Am J Clin Pathol 2000;114:599– 606. PMID: 11026107. DOI: 10.1309/ G035-P2MM-D1TM-T5QE.

39. Reid M.D., Osunkoya A.О., Siddiqui M.T., Looney S.W. Accuracy of grading of urothelial carcinoma on urine cytology: an analysis of interobserver and intraobserver agreement. Int J Clin Exp Pathol 2012;5:882–91. PMID: 23119105.

40. Raab S.S., Grzybicki D.M., Vrbin C.M., Geisinger K.R. Urine cytology discrepancies: frequency, causes, and outcomes. Am J Clin Pathol 2007;127:946–53. PMID: 17509992. DOI: 10.1309/XUVXFXMFPL7TELCE.

41. Rosenthal D.L., Vandenbussche C.J., Burroughs F.H. et al. The Johns Hopkins Hospital template for urologic cytology samples: part I-creating the template. Cancer Cytopathol 2013;121:15–20. PMID: 23192944. DOI: 10.1002/ cncy.21255.

42. Ubago J.M., Mehta V., Wojcik E.M., Barkan G.A. Evaluation of atypical urine cytology progression to malignancy. Cancer Cytopathol 2013;121:387–91. PMID: 23536358. DOI: 10.1002/ cncy.21278.

43. Koss L.G., Hoda R.S. Koss’s cytology of the urinary tract with histopathologic correlations. New York: Springer Press, 2012. Pp. 47–71.

44. Hoda R.S. Non-gynecologic cytology on liquid-based preparations: 3 morphologic review of facts and artifacts. Diagn Cytopathol 2007;35:621–34. PMID: 17854077. DOI: 10.1002/dc.20698.

45. Khaled H. Schistosomiasis and cancer in Egypt review. J Adv Res 2013;4:461–6. PMID: 25685453. DOI: 10.1016/j. jare.2013.06.007.

46. Hattori M., Nishimura Y., Toyonaga M. et al. Cytological significance of abnormal squamous cells in urinary cytology. Diagn Cytopathol 2012;40:798–803. PMID: 21309015. DOI: 10.1002/ dc.21645.

47. Gulmann C., Paner G.P., Parakh R.S. et al. Immunohistochemical profile to distinguish urothelial from squamous differentiation in carcinomas of urothelial tract. Hum Pathol 2013;44:164–72. PMID: 22995333. DOI: 10.1016/j.humpath. 2012.05.018.

48. Zhong M., Gersbach E., Rohan S.M., Yang X.J. Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance. Arch Pathol Lab Med 2013;137:371–81. PMID: 23536017. DOI: 10.1007/s00508-013-0343-1.

49. Bardales R.H., Pitman M.B., Stanley M.W. et al. Urine cytology of primary and secondary urinary bladder adenocarcinoma. Cancer 1998;34:335–43. PMID: 9915134.

50. Ciesla M.C., Guidos B.J., Selvaggi S.M. Cytomorphology of small-cell (neuroendocrine) carcinoma on ThinPrep cytology as compared to conventional smears. Diagn Cytopathol 2001;24:46–52. DOI: 10.1002/1097- 0339(200101)24:1<46:: AID-DC1008>3.0.CO;2-8.

51. Dahm P., Gschwend J.E. Malignant nonurothelial neoplasms of the urinary bladder: a review. Eur Urol 2003;44:672–81. PMID: 14644119.

52. Chalasani V., Chin J.L., Izawa J.l. Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer. Can Urol Assoc J 2009;3(6 suppl 4): Sl93–8. PMID: 20019984.

53. Westfall D.E., Folpe A.L., Paner G.P. et al. Utility of a comprehensive immunohistochemical panel in the differential diagnosis of spindle cell lesions of the urinary bladder. Am J Surg Pathol 2009;33:99–105. PMID: 18941404. DOI: 10.1097/ PAS.0b013e318180c899.

54. Cheson B.D., Schumann J.L., Schumann G.B. Urinary cytodiagnostic abnormalities in 50 patients with non-Hodgkin’s lymphomas. Cancer 1984;54:1914–9. PMID: 6478425.

55. Jimenez-Hernandez M., Lopez-Guillermo A., Cobo F. et al. Bladder involvement of diffuse large B-cell lymphoma diagnosed by a cytological study of the urine. Leuk Lymphoma 2002;43:187–9. PMID: 11908726. DOI: 10.1080/10428190210201.

56. Khalbuss W.E., Hossain M., Elhosseiny A. Primary malignant melanoma of the urinary bladder diagnosed by urine cytology: a case report. Acta Cytol 2001;45:631–5. PMID: 11480732.

57. Xiao G.Q., Chow J., Unger P.D. Metastatic tumors to the urinary bladder. Clinicopathologic study of 11 cases. Int J Surg Pathol 2012;20:342–8. PMID: 22134629. DOI: 10.1177/1066896911428736.

58. Abol-Enein H., Kava B.R., Carmack A.J. Non-urothelial cancer of the bladder. Urology 2007;69(1 suppl):93–104. PMID: 17280911. DOI: 10.1016/j.urology. 2006.08.1107.

Конфликт интересов

Авторы заявляют об отсутствии конфликта интересов.

Финансирование

Работа выполнена без спонсорской поддержки.

Для цитирования

Савостикова М. В., Кудайбергенова А. Г., Федосеева Е. С. и др. Проект рекомендаций по цитоморфологической диагностике патологии уринарного тракта. Онкопатология 2019;2(1–2):52–67.


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