Авторы: Гриневич В. Н., Максименко А. В.
DOI: 10.17650/2618-7019-2020-3-1-2-48-54
PDF: https://journal.oncopathology.ru/article/ОП_1-2_2020-50-56.pdf
В статье на примере клинического случая рассматриваются особенности дифференциальной диагностики светлоклеточного папиллярного почечно-клеточного рака с другими типами почечно-клеточного рака, которые имеют схожую морфологическую картину.
Гриневич В. Н.1, 2, Максименко А. В.2
1Московский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России; Россия, 125284 Москва, 2‑й Боткинский проезд, 3;/p>
2ГБУЗ «Московский клинический научный центр им. А. С. Логинова Департамента здравоохранения г. Москвы»; Россия, 111123 Москва, шоссе Энтузиастов, 86
1. Moch H., Humphrey P.A., Ulbright T.M., Reuter V.E. WHO classification of tumours of the urinary system and male genital organs, 4th edn. Lyon: International Agency for Research on Cancer, 2016.
2. Michal M., Hes O., Havlicek F. Benign renal angiomyoadenomatous tumor: A previously unreported renal tumor. Ann Diagnc Pathol 2000;4(5):311–5. DOI: 10.1053/adpa.2000.17890.
3. Michal M., Hes O., Nemcova J. et al. Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity. Virch Arch 2008;454(1):89–99. DOI: 10.1007/s00428-008-0697-3.
4. Tickoo S.K., dePeralta-Venturina M.N., Harik L.R. et al. Spectrum of epithelial neoplasms in end-stage renal disease. Am J Surg Pathol 2006;30(2):141–53. DOI: 10.1097/01.pas.0000185382.80844.b1.
5. Aron M., Chang E., Herrera L. et al. Clear cell-papillary renal cell carcinoma of the kidney not associated with end-stage renal disease: clinicopathologic correlation with expanded immunophenotypic and molecular characterization of a large cohort with emphasis on relationship with renal angiomyoadenomatous tumor. Am J Surg Pathol 2015;39(7):873–88. DOI: 10.1097/pas.0000000000000446.
6. Zhou H., Zheng S., Truong L.D. et al. Clear cell papillary renal cell carcinoma is the fourth most common histologic type of renal cell carcinoma in 290 consecutive nephrectomies for renal cell carcinoma. Hum Pathol 2014;45(1):59–64. DOI: 10.1016/j.humpath.2013.08.004.
7. Wang Y., Ding Y., Wang J. et al. Clinical features and survival analysis of clear cell papillary renal cell carcinoma: а 10‑year retrospective study from two institutions. Oncol Lett 2018;16(1):1010–22. DOI: 10.3892/ol.2018.8752.
8. Lin Х., Goyal R., Yang X.J. Pathologic characterization of renal epithelial neoplasms arising in non-functioning kidneys. Hum Pathol 2019. DOI: 10.1016/j.humpath.2019.09.011.
9. Anderson D.A., Tretiakova M.S. Primary renal carcinoid with bilateral multiple clear cell papillary renal cell carcinomas. Case Rep Pathol 2017;2017:9672368. DOI: 10.1155/2017/9672368.
10. Park J.H., Lee C., Suh J.H., Moon K.C. Clear cell papillary renal cell carcinoma: a report of 15 cases including three cases of concurrent other-type renal cell carcinomas. Kor J Pathol 2012;46(6):541–7. DOI: 10.4132/KoreanJPathol.2012.46.6.541.
11. Deml K.-F., Schildhaus H.-U., Compérat E. et al. Clear сell papillary renal cell carcinoma and renal angiomyoadenomatous tumor. Am J Srg Pathol 2015;39(7):889–901. DOI: 10.1097/pas.0000000000000456.
12. Hes O., Comperat E.M., Rioux-Leclercq N. Clear cell papillary renal cell carcinoma, renal angiomyoadenomatous tumor, and renal cell carcinoma with leiomyomatous stroma relationship of 3 types of renal tumors: a review. Ann Diagn Pathol 2016;21:59–64. DOI: 10.1016/j.anndiagpath.2015.11.003.
13. Dhakal H.P., McKenney J.K., Khor L.Y. et al. Renal neoplasms with overlapping features of clear cell renal cell carcinoma and clear cell papillary renal cell carcinoma: a clinicopathologic study of 37 cases from a single institution. Am J Surg Pathol 2016;40(2):141–54. DOI: 10.1097/pas.0000000000000583.
14. Alexiev B.A., Drachenberg C.B. Clear cell papillary renal cell carcinoma: incidence, morphological features, immunohistochemical profile, and biologic behavior: a single institution study. Pathol Res Pract 2014;210(4):234–41. DOI: 10.1016/j.prp.2013.12.009.
15. Mantilla J.G., Antic T., Tretiakova M. GATA3 as a valuable marker to distinguish clear cell papillary renal cell carcinomas from morphologic mimics. Hum Pathol 2017;66:152–8. DOI: 10.1016/j.humpath.2017.06.016.
16. Massari F., Ciccarese C., Hes O. et al. The tumor entity denominated “clear cellpapillary renal cell carcinoma” according to the WHO 2016 new classification, have the clinical characters of a renal cell adenoma as does harbor a benign outcome. Path Oncol Res 2017;24(3):447–56. DOI: 10.1007/s12253-017-0271-x.
17. Alshenawy H.A. Immunohistochemical panel for differentiating renal cell carcinoma with clear and papillary features. J Microsc Ultrastruct 2015;21(4):893–9. DOI: 10.1016/j.jmau.2015.01.003.
18. Fisher K.E., Yin-Goen Q., Alexis D. et al. Gene expression profiling of clear cell papillary renal cell carcinoma: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. Mod Pathol 2014;27(2):222–30. DOI: 10.1038/modpathol.2013.140.
19. Lawrie C.H., Larrea E., Larrinaga G. et al. Targeted next-generation sequencing and non-coding RNA expression analysis of clear cell papillary renal cell carcinoma suggests distinct pathological mechanisms from other renal tumour subtypes. J Pathol 2014;232(1):32–42. DOI: 10.1002/path.4296.
20. Munari E., Marchionni L., Chitre A. et al. Clear cell papillary renal cell carcinoma: micro-RNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. Hum Pathol 2014;45(6):1130–8. DOI: 10.1016/j.humpath.2014.01.013.
21. Parihar A., Tickoo S.K., Kumar S., Arora V.K. Xp11 translocation renal cell carcinoma morphologically mimicking clear cell-papillary renal cell carcinoma in an adult patient: report of a case expanding the morphologic spectrum of Xp11 translocation renal cell carcinomas. Int J Surg Pathol 2015;23(3):234–7. DOI: 10.1177/1066896914562280.
22. Zhao J., Eyzaguirre E. Clear cell papillary renal cell carcinoma. Arch Pathol Lab Med 2019;143(9):1154–8. DOI: 10.5858/arpa.2018-0121-rs.
23. Patel S., Asarian A., Xiao P. Clear cell papillary renal cell carcinoma: a case report and literature review. J Surg Case Rep 2019;2019(6):rjz177. DOI: 10.1093/jscr/rjz177.
Авторы заявляют об отсутствии конфликта интересов.
Работа выполнена без спонсорской поддержки.
Гриневич В. Н., Максименко А. В. Светлоклеточный папиллярный почечно-клеточный рак: клинический случай и обзор литературы. Онкопатология 2020;3(1–2):48–54.
![]() |
2026 №1 (Том 9) Скачать>> |