Авторы: Кудайбергенова А. Г., Сендерович А. И., Горбань Н. А.
DOI: https://doi.org/10.17650/2618-7019-2024-7-3-17-25
PDF: https://journal.oncopathology.ru/article/op_2024_3_19-27.pdf
Система репарации неспаренных оснований является одним из механизмов, лежащих в основе поддержания целостности генома. Она участвует в митотической и мейотической рекомбинации, апоптозе, перестройке генов иммуноглобулинов, соматической гипермутации и других процессах. Дефицит системы репарации неспаренных оснований (d-MMR) встречается в большинстве видов опухолей, он приводит к возникновению гипермутабельности и микросателлитной нестабильности. Определение дефицита системы репарации неспаренных оснований или микросателлитной нестабильности используется в диагностических, предиктивных и прогностических целях, в частности для скрининга синдрома Линча и выделения пациентов, которые отреагируют на терапию ингибиторами контрольных точек, а также для прогностической оценки клинического течения. В этой статье мы приводим краткий обзор практических методов определения дефицита системы репарации неспаренных оснований, уделяя особое внимание клиническому тестированию с помощью иммуногистохимической реакции, интерпретации результатов.
Кудайбергенова А. Г.1 , Сендерович А. И.2, 3, Горбань Н. А.2
1 ФГБУ «Научно-исследовательский институт онкологии им. Н.Н. Петрова» Минздрава России; Россия, 197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68;
2 ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами Президента Российской Федерации; Россия, 121359 Москва, ул. Маршала Тимошенко, 15;
3Научно-исследовательский институт урологии и интервенционной радиологии имени Н.А. Лопаткина – филиал ФГБУ «Научный медицинский исследовательский центр радиологии» Минздрава России; Россия, 105425 Москва, ул. 3-я Парковая, 51/1
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Авторы заявляют об отсутствии конфликта интересов.
Работа выполнена без спонсорской поддержки.
Кудайбергенова А. Г., Сендерович А. И., Горбань Н. А. Анализ экспрессии белков системы репарации неспаренных оснований с помощью иммуногистохимической реакции. Онкопатология 2024;7(3):17–25. DOI: https://doi.org/10.17650/2618-7019-2024-7-3-17-25
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